Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyll-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agentHONDA, Tadashi; DINKOVA-KOSTOVA, Albena T; DAVID, Emilie et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 8, pp 2188-2191, issn 0960-894X, 4 p.Article

The synthetic triterpenoid TP-222 inhibits RANKL stimulation of osteoclastogenesis and matrix metalloproteinase-9 expressionFAVA, Roy A; ELLIOTT, Sarah; RAYMOND, Lauren et al.Journal of rheumatology. 2007, Vol 34, Num 5, pp 1058-1068, issn 0315-162X, 11 p.Article

Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1 -[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]lmidazoleYATES, Melinda S; KWAK, Mi-Kyoung; HONDA, Tadashi et al.Cancer research (Baltimore). 2006, Vol 66, Num 4, pp 2488-2494, issn 0008-5472, 7 p.Article

Synthesis of a novel dicyano abietane analogue : A potential antiinflammatory agentHONDA, Tadashi; YOSHIZAWA, Hidenori; SUNDARARAJAN, Chitra et al.Journal of organic chemistry. 2006, Vol 71, Num 8, pp 3314-3316, issn 0022-3263, 3 p.Article

The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistanceCHAUHAN, Dharminder; GUILAN LI; GRIBBLE, Gordon W et al.Blood. 2004, Vol 103, Num 8, pp 3158-3166, issn 0006-4971, 9 p.Article

The anti-inflammatory triterpenoid methyl 2-cyano-3,12-dioxooleana-1,9(11 )-dien-28-oate methanol solvate hydrateBORE, Lothar; HONDA, Tadashi; GRIBBLE, Gordon W et al.Acta crystallographica. Section C, Crystal structure communications. 2002, Vol 58, pp o199-o200, issn 0108-2701, 3Article

The Acetylenic Tricyclic Bis(cyano enone), TBE-31 Inhibits Non-Small Cell Lung Cancer Cell Migration through Direct Binding with ActinCHAN, Eddie; SAITO, Akira; HONDA, Tadashi et al.Cancer prevention research (Philadelphia, Pa.). 2014, Vol 7, Num 7, pp 727-737, issn 1940-6207, 11 p.Article

Revision and confirmation of the regiochemistry of isoxazoles derived from methyl oleanonate and lanost-8-en-3-one. Synthesis of a new lanostane triterpenoid with a cyano-enone functionality in ring AHONDA, Yukiko; HONDA, Tadashi; ROY, Sujata et al.Journal of organic chemistry. 2003, Vol 68, Num 12, pp 4991-4993, issn 0022-3263, 3 p.Article

The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signalingLIBY, Karen; HOCK, Thomas; GRIBBLE, Gordon W et al.Cancer research (Baltimore). 2005, Vol 65, Num 11, pp 4789-4798, issn 0008-5472, 10 p.Article

Synthetic triterpenoids enhance transforming growth factor β/Smad signalingSUH, Nanjoo; ROBERTS, Anita B; HONDA, Tadashi et al.Cancer research (Baltimore). 2003, Vol 63, Num 6, pp 1371-1376, issn 0008-5472, 6 p.Article

The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivoPLACE, Andrew E; NANJOO SUH; ROSEN, Evan et al.Clinical cancer research. 2003, Vol 9, Num 7, pp 2798-2806, issn 1078-0432, 9 p.Article

Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemiaKONOPLEVA, Marina; TSAO, Twee; MUNSELL, Mark et al.Blood. 2002, Vol 99, Num 1, pp 326-335, issn 0006-4971Article

The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J miceLIBY, Karen; ROYCE, Darlene B; WILLIAMS, Charlotte R et al.Cancer research (Baltimore). 2007, Vol 67, Num 6, pp 2414-2419, issn 0008-5472, 6 p.Article

Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of new betulinic acid analogues having an enone functionality in ring AHONDA, Tadashi; LIBY, Karen T; GRIBBLE, Gordon W et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 24, pp 6306-6309, issn 0960-894X, 4 p.Article

A novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide productionHONDA, Tadashi; HONDA, Yukiko; FAVALORO, Frank G et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 7, pp 1027-1030, issn 0960-894XArticle

Synthetic oleanane and ursane triterpenoids with modified rings A and C : A series of highly active inhibitors of nitric oxide production in mouse macrophagesHONDA, Tadashi; ROUNDS, Barbieann V; BORE, Lothar et al.Journal of medicinal chemistry (Print). 2000, Vol 43, Num 22, pp 4233-4246, issn 0022-2623Article

2-Cyano-3,10-dioxooleana-1,9(11)-dien-28-oic acid anhydride. A novel and highly potent anti-inflammatory and cytoprotective agentHONDA, Tadashi; PADEGIMAS, Eric M; DAVID, Emilie et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 7, pp 2275-2278, issn 0960-894X, 4 p.Article

The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cellsLIBY, Karen; VOONG, Nga; WILLIAMS, Charlotte R et al.Clinical cancer research. 2006, Vol 12, Num 14, pp 4288-4293, issn 1078-0432, 6 p., 1Article

Studies on the reactivity of CDDO, a promising new chemopreventive and chemotherapeutic agent : implications for a molecular mechanism of actionCOUCH, Robin D; BROWNING, R. Greg; HONDA, Tadashi et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 9, pp 2215-2219, issn 0960-894X, 5 p.Article

Novel tricyclic compounds having acetylene groups at C-8a and cyano enones in rings A and C : Highly potent anti-inflammatory and cytoprotective agentsHONDA, Tadashi; SUNDARARAJAN, Chitra; YOSHIZAWA, Hidenori et al.Journal of medicinal chemistry (Print). 2007, Vol 50, Num 8, pp 1731-1734, issn 0022-2623, 4 p.Article

Study on the base-catalyzed reverse vinylogous aldol reaction of (4aβ,5β)-4,4a,5,6,7,8-hexahydro-5-hydroxy-1,4a-dimethylnaphthalen-2(3H)-one under robinson annulation conditionsPAYETTE, Joshua N; HONDA, Tadashi; YOSHIZAWA, Hidenori et al.Journal of organic chemistry. 2006, Vol 71, Num 1, pp 416-419, issn 0022-3263, 4 p.Article

Design, synthesis, and biological evaluation of biotin conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid for the isolation of the protein targetsHONDA, Tadashi; JANOSIK, Tomasz; HONDA, Yukiko et al.Journal of medicinal chemistry (Print). 2004, Vol 47, Num 20, pp 4923-4932, issn 0022-2623, 10 p.Article

The novel triterpenoid CDDO and its derivatives induce apoptosis by disruption of intracellular redox balanceIKEDA, Takashi; SPORN, Michael; HONDA, Tadashi et al.Cancer research (Baltimore). 2003, Vol 63, Num 17, pp 5551-5558, issn 0008-5472, 8 p.Article

Design and synthesis of tricyclic compounds with enone functionalities in rings A and C: A Novel class of highly active inhibitors of nitric oxide production in mouse macrophagesFAVALORO, Frank G; HONDA, Tadashi; HONDA, Yukiko et al.Journal of medicinal chemistry (Print). 2002, Vol 45, Num 22, pp 4801-4805, issn 0022-2623, 5 p.Article